Phosphatidylinositol 3 Kinase δ Inhibitors
نویسندگان
چکیده
منابع مشابه
Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome
The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of...
متن کاملClinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment
The phosphatidylinositol 3-kinase (PI3K) pathway is commonly deregulated in cancer. In recent years, the results of the first phase I clinical trials with PI3K inhibitors have become available. In comparison to other targeted agents such v-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitors in melanoma or crizotinib in anaplastic lymphoma receptor tyrosine kinase (ALK) translocated t...
متن کاملPhosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling occurs in one-third of human tumors. Aberrantly activated PI3K signaling also confers sensitivity and resistance to conventional therapies. PI3K has been recognized as an attractive molecular target for n...
متن کاملClass I phosphatidylinositol 3-kinase inhibitors for cancer therapy
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers. Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin (mTOR) to play key roles...
متن کاملScreening of phosphatidylinositol kinase inhibitors from Streptomyces.
Phosphatidylinositol turnover is important in intracellular signal transduction in response to various growth factors, hormones and neurotransmitters1}. Transformation by oncogenes such as ras2^, 5rc3), erbB^, fmsb) and fes^ also enhances cellular phosphatidylinositol turnover. Phosphatidylinositol kinase is an enzyme involved in the pathway of phosphatidylinositol turnover. Especially, its act...
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ژورنال
عنوان ژورنال: The Cancer Journal
سال: 2019
ISSN: 1540-336X,1528-9117
DOI: 10.1097/ppo.0000000000000414